PPIDT00287
Drug Information
| Name | Thrombin |
|---|---|
| Sequence | MARVRGPRLPGCLALAALFSLVHSQHVFLAHQQASSLLQRARRANKGFLEEVRKGNLERECLEEPCSREEAFEALESLSATDAFWAKYTACESARNPREKLNECLEGNCAEGVGMNYRGNVSVTRSGIECQLWRSRYPHKPEINSTTHPGADLRENFCRNPDGSITGPWCYTTSPTLRREECSVPVCGQDRVTVEVIPRSGGSTTSQSPLLETCVPDRGREYRGRLAVTTSGSRCLAWSSEQAKALSKDQDFNPAVPLAENFCRNPDGDEEGAWCYVADQPGDFEYCDLNYCEEPVDGDLGDRLGEDPDPDAAIEGRTSEDHFQPFFNEKTFGAGEADCGLRPLFEKKQVQDQTEKELFESYIEGRIVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTVDDLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDIALLKLKRPIELSDYIHPVCLPDKQTAAKLLHAGFKGRVTGWGNRRETWTTSVAEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRLGS |
| DrugBank_ID | DB11300 |
| Type | biotech |
| Indication | Bovine thrombin is a topical thrombin indicated to aid hemostasis whenever oozing blood and minor bleeding from capillaries and small venules is accessible and control of bleeding by standard surgical techniques (like suture, ligature, or cautery) is ineffective or impractical [FDA Label]. Additionally, topical bovine thrombin can also be used in combination with an absorbable gelatin sponge, USP [FDA Label]. |
Dosage Forms
| Form | Route | Strength |
|---|---|---|
| Solution | Topical |
|
| Solution | — |
|
| Patch | Topical |
|
| Powder, for solution | Topical |
|
| Sponge | Topical |
|
| Kit; solution | Topical |
20000 [iU]/20mL
|
| Kit; solution | Topical |
5000 [iU]/5mL
|
| Powder | Topical |
10000 unit / vial
|
| Powder | Topical |
1000 unit / vial
|
| Powder, for solution | Topical |
5000 unit / vial
|
| Powder | Topical |
|
| Kit; solution | — |
|
| Solution | Topical |
3000 KIU/ml
|
| Powder | Soft tissue |
|
Target Information
| Role | Uniprot_ID | Gene_Name | Entity_Name | Organism | Actions | Internal link |
|---|---|---|---|---|---|---|
| target | P03951 | F11 | Coagulation factor XI | Homo sapiens | activator | Link |
| target | P00488 | F13A1 | Coagulation factor XIII A chain | Homo sapiens | activator | Link |
| target | P05160 | F13B | Coagulation factor XIII B chain | Homo sapiens | activator | Link |
| target | P02671 | FGA | Fibrinogen alpha chain | Homo sapiens | activator | Link |
| target | P02675 | FGB | Fibrinogen beta chain | Homo sapiens | activator | Link |
| target | P02679 | FGG | Fibrinogen gamma chain | Homo sapiens | activator | Link |
| target | P12259 | F5 | Coagulation factor V | Homo sapiens | activator | Link |
| target | P00451 | F8 | Coagulation factor VIII | Homo sapiens | activator | Link |
| target | P25116 | F2R | Proteinase-activated receptor 1 | Homo sapiens | unknown | Link |
| target | Q96RI0 | F2RL3 | Proteinase-activated receptor 4 | Homo sapiens | unknown | Link |