PPIDT00288
Drug Information
| Name | Prothrombin |
|---|---|
| Sequence | MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE |
| DrugBank_ID | DB11311 |
| Type | biotech |
| Indication | Prothrombin is administered as part of a cocktail containing several coagulation factors. Along with other blood coagulation factors, it is used to reverse acquired coagulation factor deficiency induced by Vitamin K antagonist (VKA, e.g., warfarin) therapy in adult patients with a need for an urgent surgery/invasive procedure.[L50517] |
Dosage Forms
| Form | Route | Strength |
|---|---|---|
| Injection | Intravenous |
|
| Powder, for solution | Intravenous |
|
| Injection, powder, lyophilized, for solution; kit | Intravenous |
|
| Powder, for solution | Parenteral |
|
| Kit; powder, for solution | Intravenous |
|
| Injection, powder, for solution | Intravenous drip |
520 IU/vial
|
| Injection, powder, for solution | Parenteral |
|
| Injection, powder, for solution | Intravenous |
|
| Solution | Intravenous |
|
Target Information
| Role | Uniprot_ID | Gene_Name | Entity_Name | Organism | Actions | Internal link |
|---|---|---|---|---|---|---|
| target | P02671 | FGA | Fibrinogen alpha chain | Homo sapiens | cleavage | Link |
| target | P02675 | FGB | Fibrinogen beta chain | Homo sapiens | cleavage | Link |
| target | P00488 | F13A1 | Coagulation factor XIII A chain | Homo sapiens | agonist | Link |
| target | Q96IY4 | CPB2 | Carboxypeptidase B2 | Homo sapiens | agonist | Link |
| enzyme | P00742 | F10 | Coagulation factor X | Homo sapiens | substrate | Link |