PPIDT00293
Drug Information
| Name | Thrombin alfa |
|---|---|
| Sequence | MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE |
| DrugBank_ID | DB11572 |
| Type | biotech |
| Indication | Indicated to aid hemostasis whenever oozing blood and minor bleeding from capillaries and small venules is accessible and control of bleeding by standard surgical techniques (such as suture, ligature, or cautery) is ineffective or impractical in adults and pediatric populations greater than or equal to one month of age [FDA Label]. Additionally, thrombin alfa can be used in conjunction with an absorbable gelatin sponge, USP [FDA Label]. |
Dosage Forms
| Form | Route | Strength |
|---|---|---|
| Kit | Topical |
1000 [iU]/1mL
|
| Kit; powder, for solution | Topical |
1000 [iU]/1mL
|
| Powder, for solution | Topical |
24000 unit / vial
|
| Powder, for solution | Topical |
6000 unit / vial
|
Target Information
| Role | Uniprot_ID | Gene_Name | Entity_Name | Organism | Actions | Internal link |
|---|---|---|---|---|---|---|
| target | P12259 | F5 | Coagulation factor V | Homo sapiens | activator | Link |
| target | P00451 | F8 | Coagulation factor VIII | Homo sapiens | activator | Link |
| target | P02671 | FGA | Fibrinogen alpha chain | Homo sapiens | activator | Link |
| target | P02675 | FGB | Fibrinogen beta chain | Homo sapiens | activator | Link |
| target | P02679 | FGG | Fibrinogen gamma chain | Homo sapiens | activator | Link |