PPIDT00306

Drug Information
NameSarilumab
SequenceEVQLVESGGGLVQPGRSLRLSCAASRFTFDDYAMHWVRQAPGKGLEWVSGISWNSGRIGYADSVKGRFTISRDNAENSLFLQMNGLRAEDTALYYCAKGRDSFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
DrugBank_IDDB11767
Typebiotech
IndicationSarilumab is indicated for the treatment of following conditions: - moderately to severely active rheumatoid arthritis in adults who have had an inadequate response or intolerance to one or more diseasemodifying antirheumatic drugs (DMARDs) [L45454] - polymyalgia rheumatica in adults who have had an inadequate response to corticosteroids or who cannot tolerate corticosteroid taper [L45454] - active polyarticular juvenile idiopathic arthritis (pJIA) in patients who weigh 63 kg or greater [L51349]
Dosage Forms
Form Route Strength
Injection, solution Parenteral; Subcutaneous
150 MG
Injection, solution Parenteral; Subcutaneous
200 MG
Injection, solution Subcutaneous
150 mg/1.14mL
Injection, solution Subcutaneous
200 mg/1.14mL
Solution Subcutaneous
150 mg / 1.14 mL
Solution Subcutaneous
200 mg / 1.14 mL
Injection, solution Subcutaneous
150 mg
Injection, solution Subcutaneous
200 mg
Target Information
Role Uniprot_ID Gene_Name Entity_Name Organism Actions Internal link
target P08887 IL6R Interleukin-6 receptor subunit alpha Homo sapiens antagonist|antibody Link
target P12314 FCGR1A High affinity immunoglobulin gamma Fc receptor I Homo sapiens unknown Link
target P12318 FCGR2A Low affinity immunoglobulin gamma Fc region receptor II-a Homo sapiens unknown Link
target P31994 FCGR2B Low affinity immunoglobulin gamma Fc region receptor II-b Homo sapiens unknown Link
target P08637 FCGR3A Low affinity immunoglobulin gamma Fc region receptor III-A Homo sapiens unknown Link
target O75015 FCGR3B Low affinity immunoglobulin gamma Fc region receptor III-B Homo sapiens unknown Link
enzyme P08684 CYP3A4 Cytochrome P450 3A4 Homo sapiens inhibitor|inducer Link