PPIDT00358

Drug Information
NameEnfortumab vedotin
SequenceNot Available
DrugBank_IDDB13007
Typebiotech
IndicationEnfortumab vedotin is indicated for the treatment of adult patients with locally advanced or metastatic urothelial cancer who have previously received a programmed death receptor-1 (PD-1) or programmed death-ligand 1 (PD-L1) inhibitor, and platinum-containing chemotherapy in the neoadjuvant/adjuvant, locally advanced, or metastatic setting.[L10836,L41995] Enfortumab vedotin can also be indicated in combination with pembrolizumab in adult patients with locally advanced or metastatic urothelial cancer who are not eligible for cisplatin-containing chemotherapy under accelerated approval from the FDA.[L45813]

Dosage Forms
Form Route Strength
Injection, powder, for solution Intravenous
20 mg
Injection, powder, for solution Intravenous
30 mg
Powder, for solution Intravenous
20 mg / vial
Powder, for solution Intravenous
30 mg / vial
Solution Intravenous
20.00 mg
Powder
20 mg
Powder
30 mg
Injection, powder, lyophilized, for solution Intravenous
20 mg/2mL
Injection, powder, lyophilized, for solution Intravenous
30 mg/3mL
Target Information
Role Uniprot_ID Gene_Name Entity_Name Organism Actions Internal link
target Q96NY8 NECTIN4 Nectin-4 Homo sapiens binder|antibody Link
enzyme P08684 CYP3A4 Cytochrome P450 3A4 Homo sapiens substrate Link
transporter P08183 ABCB1 ATP-dependent translocase ABCB1 Homo sapiens substrate Link