PPIDT00365

Drug Information
NameProtein S human
SequenceMRVLGGRCGALLACLLLVLPVSEANFLSKQQASQVLVRKRRANSLLEETKQGNLERECIEELCNKEEAREVFENDPETDYFYPKYLVCLRSFQTGLFTAARQSTNAYPDLRSCVNAIPDQCSPLPCNEDGYMSCKDGKASFTCTCKPGWQGEKCEFDINECKDPSNINGGCSQICDNTPGSYHCSCKNGFVMLSNKKDCKDVDECSLKPSICGTAVCKNIPGDFECECPEGYRYNLKSKSCEDIDECSENMCAQLCVNYPGGYTCYCDGKKGFKLAQDQKSCEVVSVCLPLNLDTKYELLYLAEQFAGVVLYLKFRLPEISRFSAEFDFRTYDSEGVILYAESIDHSAWLLIALRGGKIEVQLKNEHTSKITTGGDVINNGLWNMVSVEELEHSISIKIAKEAVMDINKPGPLFKPENGLLETKVYFAGFPRKVESELIKPINPRLDGCIRSWNLMKQGASGIKEIIQEKQNKHCLVTVEKGSYYPGSGIAQFHIDYNNVSSAEGWHVNVTLNIRPSTGTGVMLALVSGNNTVPFAVSLVDSTSEKSQDILLSVENTVIYRIQALSLCSDQQSHLEFRVNRNNLELSTPLKIETISHEDLQRQLAVLDKAMKAKVATYLGGLPDVPFSATPVNAFYNGCMEVNINGVQLDLDEAISKHNDIRAHSCPSVWKKTKNS
DrugBank_IDDB13149
Typebiotech
IndicationProtein S is administered as part of a cocktail containing several other coagulation factors. Along with other blood coagulation factors, it is used to reverse acquired coagulation factor deficiency induced by Vitamin K antagonist (VKA, e.g., warfarin) therapy in adult patients with a need for an urgent surgery/invasive procedure.[L50517]

Dosage Forms
Form Route Strength
Powder, for solution Intravenous
Injection, powder, for solution Parenteral
Injection, powder, for solution Intravenous
Injection Intravenous
Injection, powder, lyophilized, for solution; kit Intravenous
Kit; powder, for solution Intravenous
Injection, powder, for solution Intravenous drip
520 IU/vial
Target Information
Role Uniprot_ID Gene_Name Entity_Name Organism Actions Internal link
target P12259 F5 Coagulation factor V Homo sapiens antagonist Link
target P00742 F10 Coagulation factor X Homo sapiens antagonist Link
target P04070 PROC Vitamin K-dependent protein C Homo sapiens cofactor Link