PPIDT00463
Drug Information
| Name | Lonapegsomatropin |
|---|---|
| Sequence | Not Available |
| DrugBank_ID | DB16220 |
| Type | biotech |
| Indication | In the US, lonepegsomatropin is indicated in the treatment of growth failure due to inadequate growth hormone secretion in patients one year and older who weigh at least 11.5 kg.[L36380] In Europe, lonepegsomatropin is indicated to treat growth failure in children and adolescents aged from three years up to 18 years due to insufficient endogenous growth hormone secretion or growth hormone deficiency.[L40139] |
Dosage Forms
| Form | Route | Strength |
|---|---|---|
| Injection, powder, for solution | Subcutaneous |
11 mg
|
| Injection, powder, for solution | Subcutaneous |
13.3 mg
|
| Injection, powder, for solution | Subcutaneous |
3 mg
|
| Injection, powder, for solution | Subcutaneous |
3.6 mg
|
| Injection, powder, for solution | Subcutaneous |
4.3 mg
|
| Injection, powder, for solution | Subcutaneous |
5.2 mg
|
| Injection, powder, for solution | Subcutaneous |
6.3 mg
|
| Injection, powder, for solution | Subcutaneous |
7.6 mg
|
| Injection, powder, for solution | Subcutaneous |
9.1 mg
|
| Injection, powder, lyophilized, for solution | Subcutaneous |
11 mg/1
|
| Injection, powder, lyophilized, for solution | Subcutaneous |
13.3 mg/1
|
| Injection, powder, lyophilized, for solution | Subcutaneous |
3 mg/1
|
| Injection, powder, lyophilized, for solution | Subcutaneous |
3.6 mg/1
|
| Injection, powder, lyophilized, for solution | Subcutaneous |
4.3 mg/1
|
| Injection, powder, lyophilized, for solution | Subcutaneous |
5.2 mg/1
|
| Injection, powder, lyophilized, for solution | Subcutaneous |
6.3 mg/1
|
| Injection, powder, lyophilized, for solution | Subcutaneous |
7.6 mg/1
|
| Injection, powder, lyophilized, for solution | Subcutaneous |
9.1 mg/1
|
Target Information
| Role | Uniprot_ID | Gene_Name | Entity_Name | Organism | Actions | Internal link |
|---|---|---|---|---|---|---|
| target | P10912 | GHR | Growth hormone receptor | Homo sapiens | ligand | Link |
| target | P16471 | PRLR | Prolactin receptor | Homo sapiens | ligand | Link |
| enzyme | P28845 | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | Homo sapiens | inhibitor | Link |
| enzyme | P05177 | CYP1A2 | Cytochrome P450 1A2 | Homo sapiens | inducer | Link |
| enzyme | P33261 | CYP2C19 | Cytochrome P450 2C19 | Homo sapiens | inhibitor | Link |
| transporter | P08183 | ABCB1 | ATP-dependent translocase ABCB1 | Homo sapiens | substrate | Link |