PPIDT00465
Drug Information
| Name | Nirsevimab |
|---|---|
| Sequence | QVQLVQSGAEVKKPGSSVMVSCQASGGLLEDYIINWVRQAPGQGPEWMGGIIPVLGTVHYGPKFQGRVTITADESTDTAYMELSSLRSEDTAMYYCATETALVVSETYLPHYFDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLEGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK |
| DrugBank_ID | DB16258 |
| Type | biotech |
| Indication | Nirsevimab is indicated for the prevention of respiratory syncytial virus (RSV) lower respiratory tract disease in neonates and infants during their first RSV season in Canada, the US, and Europe.[L44146,L46392] Additionally, Nirsevimab is also approved in Canada and the US for use in infants up to 24 months of age who remain vulnerable to severe RSV disease through their second RSV season.[L46392, L47456] These infants include, but are not limited to, those with chronic lung disease of prematurity, hemodynamically significant congenital heart disease, immunocompromised states, Down syndrome, cystic fibrosis, neuromuscular disease, and congenital airway anomalies.[L46392] |
Dosage Forms
| Form | Route | Strength |
|---|---|---|
| Injection | Intramuscular |
100 mg/1mL
|
| Injection | Intramuscular |
50 mg/0.5mL
|
| Injection, solution | Intramuscular |
100 mg
|
| Injection, solution | Intramuscular |
50 mg
|
| Solution | Intramuscular |
100 mg / 1 mL
|
| Solution | Intramuscular |
50 mg / 0.5 mL
|
Target Information
| Role | Uniprot_ID | Gene_Name | Entity_Name | Organism | Actions | Internal link |
|---|---|---|---|---|---|---|
| target | P13843 | F | Fusion glycoprotein F0 | Human respiratory syncytial virus B (strain 18537) | antibody | Link |
| target | P03420 | F | Fusion glycoprotein F0 | Human respiratory syncytial virus A (strain A2) | antibody | Link |
| target | P11209 | F | Fusion glycoprotein F0 | Human respiratory syncytial virus A (strain RSS-2) | antibody | Link |