PPIRE00035

Target Protein Information
Protein_Name Gastrin-releasing peptide receptor
Protein_Sequence MAPNNCSHLNLDVDPFLSCNDTFNQSLSPPKMDNWFHPGFIYVIPAVYGLIIVIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASKYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAALIWIVSMLLAIPEAVFSDLHPFHVKDTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLAIISVYYYFIARNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLMNRSHSTGRSTTCMTSFKSTNPSATFSLINRNICHEGYV
Organism_Source Mus musculus
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names Grpr
UniProt_ID P21729
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Compound 2
Peptide_Sequence HWAVGHLL
Peptide_Length 8
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)C(=O)O
Chemical_Modification CH2O bond between L7 and L8
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 932.09
Aliphatic_Index 146.25000
Aromaticity 0.12500
Average_Rotatable_Bonds 3.25000
Charge_at_pH_7 0.17980
Isoelectric_Point 7.71436
Number_of_Hydrogen_Bond_Acceptors 11
Number_of_Hydrogen_Bond_Donors 12
Topological_Polar_Surface_Area 340.17000
X_logP_energy -0.15300
Interaction Information
Affinity IC50=2.1 nM
Affinity_Assay Radioligand Binding Assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title A gastrin-releasing peptide antagonist containing A psi (CH2O)amide bond surrogate.
Release_Year 1989
PMID 2590213
DOI 10.1016/0006-291x(89)91041-3