PPIRE00045

Target Protein Information
Protein_Name Dipeptidyl peptidase 1
Protein_Sequence MGPWSGSRLVALLLLVYGAGSVRGDTPANCTYPDLLGTWVFQVGSSGSQRDVNCSVMGPPEKKVVVHLKKLDTAYDDFGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGGKVTSYCHETMTGWVHDVLGRNRACFTGRKTGNTSENVNVNTARLAGLEETYSNRLYRYNHDFVKAINAIQKSWTAAPYMEYETLTLKEMIRRGGGHSRRIPRPKPAPITAEIQKKILHLPTSWDWRNVHGINFVTPVRNQGSCGSCYSFASMGMMEARIRILTNNTQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEDCFPYTGTDSPCRLKEGCFRYYSSEYHYVGGFYGGCNEALMKLELVHQGPMAVAFEVYDDFLHYRKGVYHHTGLRDPFNPFELTNHAVLLVGYGTDAASGLDYWIVKNSWGTSWGENGYFRIRRGTDECAIESIALAATPIPKL
Organism_Source Bos taurus
Functional_Classification Protease
Cellular_Localization Lysosome
Gene_Names CTSC
UniProt_ID Q3ZCJ8
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Ac-(R)8-NH2
Peptide_Sequence RRRRRRRR
Peptide_Length 8
Peptide_SMILES N=C(N)NCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1267.52
Aliphatic_Index 0.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 5.87500
Charge_at_pH_7 7.99796
Isoelectric_Point 13.34511
Number_of_Hydrogen_Bond_Acceptors 17
Number_of_Hydrogen_Bond_Donors 33
Topological_Polar_Surface_Area 762.22000
X_logP_energy -10.10194
Interaction Information
Affinity IC50=1.2 nM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Arginine-based structures are specific inhibitors of cathepsin C. Application of peptide combinatorial libraries.
Release_Year 2000
PMID 10824120
DOI 10.1046/j.1432-1327.2000.01364.x