PPIRE00371

Target Protein Information
Protein_Name SPRY domain-containing SOCS box protein 2
Protein_Sequence MGQTALARGSSSTPTSQALYSDFSPPEGLEELLSAPPPDLVAQRHHGWNPKDCSENIDVKEGGLCFERRPVAQSTDGVRGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAPLQADHYAALLGSNSESWGWDIGRGKLYHQSKGLEAPQYPAGPQGEQLVVPERLLVVLDMEEGTLGYSIGGTYLGPAFRGLKGRTLYPSVSAVWGQCQVRIRYMGERRVEEPQSLLHLSRLCVRHALGDTRLGQISTLPLPPAMKRYLLYK
Organism_Source Mus musculus
Functional_Classification E3 ubiquitin ligase adaptors
Cellular_Localization Cytoplasm
Gene_Names Spsb2
UniProt_ID O88838
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name [A66D]hPar-4(59-77)
Peptide_Sequence GTPAAAADNELNNNLPGGA
Peptide_Length 19
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1766.84
Aliphatic_Index 67.36842
Aromaticity 0.00000
Average_Rotatable_Bonds 2.78947
Charge_at_pH_7 -1.99979
Isoelectric_Point 3.55007
Number_of_Hydrogen_Bond_Acceptors 27
Number_of_Hydrogen_Bond_Donors 25
Topological_Polar_Surface_Area 836.73000
X_logP_energy -13.55510
Interaction Information
Affinity KD=190 nM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4.
Release_Year 2010
PMID 20561531
DOI 10.1016/j.jmb.2010.06.017