PPIRE00373

Target Protein Information
Protein_Name SPRY domain-containing SOCS box protein 1
Protein_Sequence MGQKVTGGIKTVDMRDPTYRPLKQELQGLDYCKPTRLDLLLDMPPVSYDVQLLHSWNNNDRSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGKNQPSKTYPAFLEPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWGHCEIRMRYLNGLDPEPLPLMDLCRRSVRLALGRERLGEIHTLPLPASLKAYLLYQ
Organism_Source Homo sapiens
Functional_Classification E3 ubiquitin ligase adaptors
Cellular_Localization Cytoplasm
Gene_Names SPSB1
UniProt_ID Q96BD6
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name hPar-4
Peptide_Sequence NELNNNLPGGAPAAP
Peptide_Length 15
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1448.56
Aliphatic_Index 72.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 2.73333
Charge_at_pH_7 -1.00024
Isoelectric_Point 3.84998
Number_of_Hydrogen_Bond_Acceptors 21
Number_of_Hydrogen_Bond_Donors 18
Topological_Polar_Surface_Area 654.01000
X_logP_energy -9.51480
Interaction Information
Affinity KD=1000 nM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 2JK9
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4.
Release_Year 2010
PMID 20561531
DOI 10.1016/j.jmb.2010.06.017