PPIRE00678
Target Protein Information
| Protein_Name | Histone H2AX |
|---|---|
| Protein_Sequence | MSGRGKTGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGHYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKKTSATVGPKAPSGGKKATQASQEY |
| Organism_Source | Homo sapiens |
| Functional_Classification | histones |
| Cellular_Localization | nucleus |
| Gene_Names | H2AX |
| UniProt_ID | P16104 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | CARP-1(636-650)peptide |
|---|---|
| Peptide_Sequence | PKTMKVNDLRKELES |
| Peptide_Length | 15 |
| Peptide_SMILES | CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)O)C(C)C |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Biotin |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1788.09 |
|---|---|
| Aliphatic_Index | 71.33333 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 4.33333 |
| Charge_at_pH_7 | 1.00109 |
| Isoelectric_Point | 9.43992 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 27 |
| Number_of_Hydrogen_Bond_Donors | 28 |
| Topological_Polar_Surface_Area | 792.14000 |
| X_logP_energy | -7.78543 |
Interaction Information
| Affinity | KD=127 nM |
|---|---|
| Affinity_Assay | Surface plasmon resonance |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | A H2AX?CARP-1 Interaction Regulates Apoptosis Signaling Following DNA Damage. |
| Release_Year | 2019 |
| PMID | 30769864 |
| DOI | 10.3390/cancers11020221 |