PPIRE00725
Target Protein Information
| Protein_Name | Calcitonin gene-related peptide type 1 receptor |
|---|---|
| Protein_Sequence | MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSASYTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN |
| Organism_Source | Homo sapiens |
| Functional_Classification | G protein-coupled receptor |
| Cellular_Localization | plasma membrane |
| Gene_Names | CALCRL |
| UniProt_ID | Q16602 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Calcitonin gene-related peptide |
|---|---|
| Peptide_Sequence | HSDAVFTDNYTRLRKQMAVKKYLKLSYSGHMG |
| Peptide_Length | 32 |
| Peptide_SMILES | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)NCC(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 3746.32 |
|---|---|
| Aliphatic_Index | 60.93750 |
| Aromaticity | 0.12500 |
| Average_Rotatable_Bonds | 3.96875 |
| Charge_at_pH_7 | 4.17696 |
| Isoelectric_Point | 10.36042 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 55 |
| Number_of_Hydrogen_Bond_Donors | 57 |
| Topological_Polar_Surface_Area | 1573.28000 |
| X_logP_energy | -15.42326 |
Interaction Information
| Affinity | IC50=1 nM |
|---|---|
| Affinity_Assay | organ bath assay |
| PDB_ID | None |
| Type | Agonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Cutaneous sensory stimulation leading to facial flushing and release of calcitonin gene-related peptide. |
| Release_Year | 1992 |
| PMID | 1559259 |
| DOI | 10.1046/j.1468-2982.1992.1201053.x |