PPIRE00726

Target Protein Information
Protein_Name Delta-type opioid receptor
Protein_Sequence MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTACTPSDGPGGGAAA
Organism_Source Rattus norvegicus
Functional_Classification G protein-coupled receptor
Cellular_Localization plasma membrane
Gene_Names Oprd1
UniProt_ID P33533
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name deltorphin I
Peptide_Sequence YaFDVVG
Peptide_Length 7
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)NCC(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 769.85
Aliphatic_Index 97.14286
Aromaticity 0.28571
Average_Rotatable_Bonds 3.00000
Charge_at_pH_7 -1.00242
Isoelectric_Point 3.74999
Number_of_Hydrogen_Bond_Acceptors 10
Number_of_Hydrogen_Bond_Donors 10
Topological_Polar_Surface_Area 295.45000
X_logP_energy -1.06390
Interaction Information
Affinity IC50=0.6 nM
Affinity_Assay radioligand binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Synthesis, biology, NMR and conformation studies of the topographically constrained delta-opioid selective peptide analogs of [beta-iPrPhe(3)]deltorphin I.
Release_Year 2001
PMID 11328484
DOI 10.1046/j.1397-002x.2000.00000.x