PPIRE00745

Target Protein Information
Protein_Name Myc proto-oncogene protein
Protein_Sequence MDFFRVVENQQPPATMPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNPARGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLSSTESSPQGSPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSAGGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQISNNRKCTSPRSSDTEENVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQAEEQKLISEEDLLRKRREQLKHKLEQLRNSCA
Organism_Source Homo sapiens
Functional_Classification proto-oncogene transcription factor
Cellular_Localization nucleus
Gene_Names MYC
UniProt_ID P01106
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Pmyc
Peptide_Sequence KGGGTGGGGK
Peptide_Length 10
Peptide_SMILES C[C@@H](O)[C@H](NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@@H](N)CCCCN)C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 774.83
Aliphatic_Index 0.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 2.80000
Charge_at_pH_7 1.99739
Isoelectric_Point 10.80538
Number_of_Hydrogen_Bond_Acceptors 14
Number_of_Hydrogen_Bond_Donors 14
Topological_Polar_Surface_Area 397.49000
X_logP_energy -8.17990
Interaction Information
Affinity KD=5 nM
Affinity_Assay Surface plasmon resonance
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title High-affinity homologous peptide nucleic acid probes for targeting a quadruplex-forming sequence from a MYC promoter element.
Release_Year 2007
PMID 17718513
DOI 10.1021/bi700854r