PPIRE00818
Target Protein Information
| Protein_Name | Transporter |
|---|---|
| Protein_Sequence | MNELATPLIKSAKDRHRTELQNSGQSTAHVCQRPFGRMETTPLNSQRELSAYKDGDDCQENGVLWKGLPAPGDKAESSHISNGYSAVPSPGAGDDTQNSIPAATTALVAEVHPGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGFAICVIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNVTWMLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTIIYFSIWKGVKTSGKVVWVTATFPYIILSILLVRGATLPGAWRGVLFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCSRDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHFWSKRREWLALGVVITCFLGSLITLTFGGAYVVKLLEEFATGPAVLTVALIEAVAVFWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLVFIICSFLMSPPQLWLFQYNYPQWSIILGYCIGTSSFICIPTYITYRLIITPGTLKERIVKGITPETPTEIPCGDIRLNAV |
| Organism_Source | Sus scrofa |
| Functional_Classification | protease |
| Cellular_Localization | extracellular |
| Gene_Names | SLC6A4 |
| UniProt_ID | A0A8D1BAW8 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | His-Leu-Leu-Val-Phe-OCH3 |
|---|---|
| Peptide_Sequence | HLLVF |
| Peptide_Length | 5 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | methyl esterification |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 627.78 |
|---|---|
| Aliphatic_Index | 214.00000 |
| Aromaticity | 0.20000 |
| Average_Rotatable_Bonds | 3.60000 |
| Charge_at_pH_7 | 0.08889 |
| Isoelectric_Point | 7.55032 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 7 |
| Number_of_Hydrogen_Bond_Donors | 7 |
| Topological_Polar_Surface_Area | 208.40000 |
| X_logP_energy | 1.29420 |
Interaction Information
| Affinity | Ki=0.8 uM |
|---|---|
| Affinity_Assay | Enzyme Inhibition Kinetics |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Effects of certain hallucinogenic amphetamine analogues on the release of [3H]serotonin from rat brain synaptosomes. |
| Release_Year | 1983 |
| PMID | 7086839 |
| DOI | 10.1021/jm00347a010 |