PPIRE00820

Target Protein Information
Protein_Name None
Protein_Sequence ENSRIFFGCLLLLLILLLLFVFLISPEISPDFMRGFVTVNSSKLELLISVGLFLILIGLVIEAYLEEQRINTQLLNNLTIYTEKIESINEELAMFRHDYKNLLYSLQIAISYEDILEIKRIYEETIAPTKKIIDNEEFELMKLNRLKNMELKALISMKINTAKQAKLKVIVDVPEVFIL
Organism_Source Enterococcus faecalis
Functional_Classification histidine kinase
Cellular_Localization plasma membrane
Gene_Names fsrC
UniProt_ID A0A248QKI7
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name ZBzl-YAA5911
Peptide_Sequence IRSPXIFGAWA
Peptide_Length 11
Peptide_SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)O)[C@@H](C)CC
Chemical_Modification X5=Tyr(Bzl)
Cyclization_Method Main chain-side chain cyclization; S3<->A11; other bonds
Linear/Cyclic Cyclic
N-terminal_Modification Benzyloxycarbonyl
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1174.37
Aliphatic_Index 89.09091
Aromaticity 0.18182
Average_Rotatable_Bonds 3.00000
Charge_at_pH_7 0.99798
Isoelectric_Point 10.55000
Number_of_Hydrogen_Bond_Acceptors 14
Number_of_Hydrogen_Bond_Donors 16
Topological_Polar_Surface_Area 443.45000
X_logP_energy -2.63043
Interaction Information
Affinity IC50=26.2 nM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Development of a peptide antagonist against fsr quorum sensing of Enterococcus faecalis.
Release_Year 2013
PMID 23362999
DOI 10.1021/cb300717f