PPIRE00840

Target Protein Information
Protein_Name Troponin C, slow skeletal and cardiac muscles
Protein_Sequence MDDIYKAAVEQLTEEQKNEFKAAFDIFVLGAEDGCISTKELGKVMRMLGQNPTPEELQEMIDEVDEDGSGTVDFDEFLVMMVRCMKDDSKGKSEEELSDLFRMFDKNADGYIDLDELKIMLQATGETITEDDIEELMKDGDKNNDGRIDYDEFLEFMKGVE
Organism_Source Oryctolagus cuniculus
Functional_Classification EF-hand calcium-binding proteins
Cellular_Localization Cytoplasm
Gene_Names TNNC1
UniProt_ID P02591
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Ac(Asn-103
Peptide_Sequence NRDANGYIDAEEL
Peptide_Length 13
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1479.52
Aliphatic_Index 75.38462
Aromaticity 0.07692
Average_Rotatable_Bonds 3.76923
Charge_at_pH_7 -2.99843
Isoelectric_Point 3.73792
Number_of_Hydrogen_Bond_Acceptors 22
Number_of_Hydrogen_Bond_Donors 24
Topological_Polar_Surface_Area 730.03000
X_logP_energy -8.37933
Interaction Information
Affinity KD=66.67 uM
Affinity_Assay 1H NMR spectroscopy
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title 1H-NMR studies of synthetic peptide analogues of calcium-binding site III of rabbit skeletal troponin C: effect on the lanthanum affinity of the interchange of aspartic acid and asparagine residues at the metal ion coordinating positions.
Release_Year 1988
PMID 3415981
DOI 10.1021/bi00411a043