PPIRE00847

Target Protein Information
Protein_Name Protein Tat
Protein_Sequence MEPVDPRLEPWNHPGSQPKTACNNCYCKRCCYHCLYCFTKKGLGISYGRKKRSQRRRTPQSSKSHQDLIPEQPLSQQQGDQTGQKKQKEALESKTEADPCD
Organism_Source Human immunodeficiency virus type 1 group N (isolate YBF30)
Functional_Classification RNA-binding element
Cellular_Localization nucleus
Gene_Names tat
UniProt_ID O91083
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Tat-20
Peptide_Sequence YGRKKRRQRRRPPQGPGGPP
Peptide_Length 20
Peptide_SMILES N=C(N)NCCC[C@H](NC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2344.72
Aliphatic_Index 0.00000
Aromaticity 0.05000
Average_Rotatable_Bonds 3.70000
Charge_at_pH_7 7.99652
Isoelectric_Point 12.80804
Number_of_Hydrogen_Bond_Acceptors 32
Number_of_Hydrogen_Bond_Donors 39
Topological_Polar_Surface_Area 1102.12000
X_logP_energy -14.01698
Interaction Information
Affinity KD=0.93 mM
Affinity_Assay 1H NMR spectroscopy
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Kinetic characterization of TAR RNA-Tat peptide and neomycin interactions by acoustic wave biosensor.
Release_Year 2003
PMID 14556896
DOI 10.1016/S0301-4622(03)00155-8