PPIRE00864

Target Protein Information
Protein_Name Natriuretic peptides B
Protein_Sequence MGPRMALPRVLLLLFLHLLLLGCRSHPLGGAGLASELPGIQELLDRLRDRVSELQAERTDLEPLRQDRGLTEAWEAREAAPTGVLGPRSSIFQVLRGIRSPKTMRDSGCFGRRLDRIGSLSGLGCNVLRRY
Organism_Source Sus scrofa
Functional_Classification G protein-coupled receptor
Cellular_Localization plasma membrane
Gene_Names NPPB
UniProt_ID P07634
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Human BNP
Peptide_Sequence SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRHISGL
Peptide_Length 36
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CS)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)CNC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CO)C(C)C)[C@@H](C)CC)C(C)C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)O
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; Cys10<->Cys26; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3836.53
Aliphatic_Index 70.27778
Aromaticity 0.02778
Average_Rotatable_Bonds 3.72222
Charge_at_pH_7 5.96449
Isoelectric_Point 11.58025
Number_of_Hydrogen_Bond_Acceptors 58
Number_of_Hydrogen_Bond_Donors 63
Topological_Polar_Surface_Area 1649.37000
X_logP_energy -22.09592
Interaction Information
Affinity IC50=0.02 nM
Affinity_Assay organ bath vascular relaxation assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Receptors for atrial natriuretic peptide (ANP)and cyclic GMP responses in HeLa cells
Release_Year 1990
PMID 2158313
DOI 10.1016/0006-291x(90)91686-m