PPIRE00866
Target Protein Information
| Protein_Name | Natriuretic peptides B |
|---|---|
| Protein_Sequence | MGPRMALPRVLLLLFLHLLLLGCRSHPLGGAGLASELPGIQELLDRLRDRVSELQAERTDLEPLRQDRGLTEAWEAREAAPTGVLGPRSSIFQVLRGIRSPKTMRDSGCFGRRLDRIGSLSGLGCNVLRRY |
| Organism_Source | Sus scrofa |
| Functional_Classification | G protein-coupled receptor |
| Cellular_Localization | plasma membrane |
| Gene_Names | NPPB |
| UniProt_ID | P07634 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Porcine BNP |
|---|---|
| Peptide_Sequence | XXXFGIXXXXIGXXXXXX |
| Peptide_Length | 18 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)CN)[C@@H](C)CC)C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | Side chain-side chain cyclization; Cys10<->Cys26; disulfide bond |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1247.29 |
|---|---|
| Aliphatic_Index | 43.33333 |
| Aromaticity | 0.05556 |
| Average_Rotatable_Bonds | 2.27778 |
| Charge_at_pH_7 | -0.00202 |
| Isoelectric_Point | 6.10000 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 19 |
| Number_of_Hydrogen_Bond_Donors | 19 |
| Topological_Polar_Surface_Area | 558.02000 |
| X_logP_energy | -11.55420 |
Interaction Information
| Affinity | IC50=1.11 nM |
|---|---|
| Affinity_Assay | organ bath vascular relaxation assay |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Receptors for atrial natriuretic peptide (ANP)and cyclic GMP responses in HeLa cells |
| Release_Year | 1990 |
| PMID | 2158313 |
| DOI | 10.1016/0006-291x(90)91686-m |