PPIRE00943

Target Protein Information
Protein_Name Galanin receptor type 1
Protein_Sequence MELAPVNLSEGNGSDPEPPAEPRPLFGIGVENFITLVVFGLIFAMGVLGNSLVITVLARSKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGFIWALSIAMASPVAYYQRLFHRDSNQTFCWEHWPNQLHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLKNMSKKSEASKKKTAQTVLVVVVVFGISWLPHHVIHLWAEFGAFPLTPASFFFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCRVCNESPHGDAKEKNRIDTPPSTNCTHV
Organism_Source Rattus norvegicus
Functional_Classification G protein-coupled receptor
Cellular_Localization plasma membrane
Gene_Names Galr1
UniProt_ID Q62805
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Galanin
Peptide_Sequence GWTLNSAGYLLGPHAKLSLTTGISQEKYI
Peptide_Length 29
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3119.57
Aliphatic_Index 101.03448
Aromaticity 0.10345
Average_Rotatable_Bonds 3.44828
Charge_at_pH_7 1.08838
Isoelectric_Point 9.12426
Number_of_Hydrogen_Bond_Acceptors 44
Number_of_Hydrogen_Bond_Donors 44
Topological_Polar_Surface_Area 1251.16000
X_logP_energy -11.66360
Interaction Information
Affinity IC50=7 nM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Evidence for an inhibitory effect of the peptide galanin on dopamine release from the rat median eminence.
Release_Year 1987
PMID 2436097
DOI 10.1016/0304-3940(87)90024-3