PPIRE00944

Target Protein Information
Protein_Name Calcitonin gene-related peptide type 1 receptor
Protein_Sequence MEKMCVLYFLFLLPFVMCLATAEPEEQSNDTMHLRVTRNKIMTAQYECYQKIMQDPVQQIEGIYCNRTWDGWLCWNDVAAGTESMQHCPDYFQDFDPSEKVTKICNKDGNWFRHPESNRTWTNYTQCNVNTPEKVKTALNLFYLTIIGHGLSITSLVISLGIFFYFKSLSCQRITLHKNLFFSFVCNSTVTIIHFTAVANNQALVATNPVSCKVSQFIHLYLLGCNYFWMLCEGIYLHTLIVVAVFAEKQHLIWYYFLGWGFPLIPACIHAIARSLYYNDNCWISFDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESHLYMKAVRATLILVPLLGIEFVLLPWRPEGRIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGHSFSHSDALRSASYTVSTISDGPGFSHDCASEHLNGKSIHDTDNMVLKPEKLKDLAI
Organism_Source Cavia porcellus
Functional_Classification G protein-coupled receptor
Cellular_Localization plasma membrane
Gene_Names CALCRL
UniProt_ID H0UV86
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name human calcitonin gene-related peptide
Peptide_Sequence HSDGTFTSDYSKFISSSQTQEQLVANKESSGRQQSSM
Peptide_Length 37
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)O)C(C)C)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 4084.31
Aliphatic_Index 31.62162
Aromaticity 0.08108
Average_Rotatable_Bonds 3.81081
Charge_at_pH_7 -0.90811
Isoelectric_Point 5.59473
Number_of_Hydrogen_Bond_Acceptors 67
Number_of_Hydrogen_Bond_Donors 68
Topological_Polar_Surface_Area 1944.50000
X_logP_energy -31.49683
Interaction Information
Affinity KD=0.72 nM
Affinity_Assay saturation binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Autoradiographic localization of calcitonin gene-related peptide (CGRP)binding sites in human and guinea pig lung.
Release_Year 1988
PMID 2854248
DOI 10.1016/0196-9781(88)90073-3