PPIRE00963

Target Protein Information
Protein_Name Interleukin-1 receptor type 1
Protein_Sequence MENMKVLLGLICLMVPLLSLEIDVCTEYPNQIVLFLSVNEIDIRKCPLTPNKMHGDTIIWYKNDSKTPISADRDSRIHQQNEHLWFVPAKVEDSGYYYCIVRNSTYCLKTKVTVTVLENDPGLCYSTQATFPQRLHIAGDGSLVCPYVSYFKDENNELPEVQWYKNCKPLLLDNVSFFGVKDKLLVRNVAEEHRGDYICRMSYTFRGKQYPVTRVIQFITIDENKRDRPVILSPRNETIEADPGSMIQLICNVTGQFSDLVYWKWNGSEIEWNDPFLAEDYQFVEHPSTKRKYTLITTLNISEVKSQFYRYPFICVVKNTNIFESAHVQLIYPVPDFKNYLIGGFIILTATIVCCVCIYKVFKVDIVLWYRDSCSGFLPSKASDGKTYDAYILYPKTLGEGSFSDLDTFVFKLLPEVLEGQFGYKLFIYGRDDYVGEDTIEVTNENVKKSRRLIIILVRDMGGFSWLGQSSEEQIAIYNALIQEGIKIVLLELEKIQDYEKMPDSIQFIKQKHGVICWSGDFQERPQSAKTRFWKNLRYQMPAQRRSPLSKHRLLTLDPVRDTKEKLPAATHLPLG
Organism_Source Mus musculus
Functional_Classification cytokine receptors
Cellular_Localization plasma membrane
Gene_Names Il1r1
UniProt_ID P13504
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Perthamide B
Peptide_Sequence XXXXXXX
Peptide_Length 7
Peptide_SMILES NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)O
Chemical_Modification X1=Asn; X2=3-amino-2-hydroxy-6-methyloctanoic acid; X3=2,3-dehydro-2-aminobutyric acid; X4=N-methylglycine; X5=O-methylthreonine; X6=4-methylproline; X7=3-bromotyrosine
Cyclization_Method Main chain-main chain cyclization; X1<->X7; amide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification None
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 417.38
Aliphatic_Index 0.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 1.85714
Charge_at_pH_7 -0.00202
Isoelectric_Point 6.10000
Number_of_Hydrogen_Bond_Acceptors 8
Number_of_Hydrogen_Bond_Donors 8
Topological_Polar_Surface_Area 237.92000
X_logP_energy -6.27310
Interaction Information
Affinity IC50=27.6 uM
Affinity_Assay radioligand binding assay
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Receptors for atrial natriuretic peptide (ANP)and cyclic GMP responses in HeLa cells
Release_Year 1994
PMID 2158313
DOI 10.1016/0040-4039(94)01435-3