PPIRE00967

Target Protein Information
Protein_Name Calcitonin gene-related peptide type 1 receptor
Protein_Sequence MMDKKCTLCFLFLLLLNMALIAAESEEGANQTDLGVTRNKIMTAQYECYQKIMQDPIQQGEGLYCNRTWDGWLCWNDVAAGTESMQYCPDYFQDFDPSEKVTKICDQDGNWFRHPDSNRTWTNYTLCNNSTHEKVKTALNLFYLTIIGHGLSIASLIISLIIFFYFKSLSCQRITLHKNLFFSFVCNSIVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLLPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLFPWRPEGKVAEEVYDYVMHILMHYQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNGFSHSDALRSASYTVSTISDVQGYSHDCPTEHLNGKSIQDIENVALKPEKMYDLVM
Organism_Source Rattus norvegicus
Functional_Classification G protein-coupled receptor
Cellular_Localization plasma membrane
Gene_Names Calcrl
UniProt_ID Q63118
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name human CGRP
Peptide_Sequence XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
Peptide_Length 37
Peptide_SMILES NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)O
Chemical_Modification Unknown
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2128.94
Aliphatic_Index 0.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 1.97297
Charge_at_pH_7 -0.00202
Isoelectric_Point 6.10000
Number_of_Hydrogen_Bond_Acceptors 38
Number_of_Hydrogen_Bond_Donors 38
Topological_Polar_Surface_Area 1110.92000
X_logP_energy -32.78710
Interaction Information
Affinity KD=2.13 nM
Affinity_Assay radioligand autoradiography
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Demonstration of calcitonin gene-related peptide receptors in the gubernaculum by computerized densitometry.
Release_Year 1992
PMID 1322457
DOI 10.1016/0022-3468(92)90389-o