PPIRE00991

Target Protein Information
Protein_Name Substance-P receptor
Protein_Sequence MDNVLPVDSDLFPNTSTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQSSVYKVSRLETTISTVVGAHEDEPEEGPKATPSSLDLTSNGSSRSNSKTMTESSSFYSNMLA
Organism_Source Mus musculus
Functional_Classification G protein-coupled receptor
Cellular_Localization plasma membrane
Gene_Names Tacr1
UniProt_ID P30548
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name bufokinin
Peptide_Sequence KPRPDQFYGLM
Peptide_Length 11
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1351.59
Aliphatic_Index 35.45455
Aromaticity 0.18182
Average_Rotatable_Bonds 3.72727
Charge_at_pH_7 0.99728
Isoelectric_Point 9.29736
Number_of_Hydrogen_Bond_Acceptors 18
Number_of_Hydrogen_Bond_Donors 17
Topological_Polar_Surface_Area 525.28000
X_logP_energy -2.98723
Interaction Information
Affinity KD=0.57 nM
Affinity_Assay radioligand saturation binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Pharmacological and biochemical investigation of receptors for the toad gut tachykinin peptide, bufokinin, in its species of origin.
Release_Year 1999
PMID 10494889
DOI 10.1007/s002109900069