PPIRE01003

Target Protein Information
Protein_Name None
Protein_Sequence MRAGQRPRLRSRPRGCSKMWDNLTCWPATPPGQVVVLDCPLIYKFFSPVQGRNVSRSCTNEGWTHLEPGPYPIACGLNDKASDLEEQSMFYSSVKTIYTVGHSLSLAALLVATAILSLFRKLHCTRNYIHMHLFISFILRATAVFIKDLILFNSEDVDYCTKGSVSCKAAMVLFQYCIMANFFWLLVEGLYLHTLLAVSFFSERKYFWGYILIGWGVPSIFTIVWTIIRLYFEDTGCWNTINSSFWWIIKAPILTSILVNFILFICIIRILVQKLQSPDVGKSHSSPYSRLAKSTLLLIPLFGVHYIMFAFFPNNFTAEVKMVFELVMGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGFLGSDPKYQHPSGGSNGATCSTQVSILTRVSPGARRSSSFQAEVSLV
Organism_Source Felis catus
Functional_Classification G protein-coupled receptor
Cellular_Localization plasma membrane
Gene_Names VIPR1
UniProt_ID M3WAP5
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name PHI1-27
Peptide_Sequence HSDAVFTDNYTRLRKQMAVKKYLNSILI
Peptide_Length 28
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3325.88
Aliphatic_Index 97.50000
Aromaticity 0.10714
Average_Rotatable_Bonds 4.03571
Charge_at_pH_7 3.08719
Isoelectric_Point 10.32468
Number_of_Hydrogen_Bond_Acceptors 47
Number_of_Hydrogen_Bond_Donors 50
Topological_Polar_Surface_Area 1404.81000
X_logP_energy -12.44616
Interaction Information
Affinity IC50=132 nM
Affinity_Assay radioligand competition binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Receptors for atrial natriuretic peptide (ANP)and cyclic GMP responses in HeLa cells.
Release_Year 1990
PMID 2158313
DOI 10.1016/0006-291x(90)91686-m