PPIRE01005

Target Protein Information
Protein_Name None
Protein_Sequence MRAGQRPRLRSRPRGCSKMWDNLTCWPATPPGQVVVLDCPLIYKFFSPVQGRNVSRSCTNEGWTHLEPGPYPIACGLNDKASDLEEQSMFYSSVKTIYTVGHSLSLAALLVATAILSLFRKLHCTRNYIHMHLFISFILRATAVFIKDLILFNSEDVDYCTKGSVSCKAAMVLFQYCIMANFFWLLVEGLYLHTLLAVSFFSERKYFWGYILIGWGVPSIFTIVWTIIRLYFEDTGCWNTINSSFWWIIKAPILTSILVNFILFICIIRILVQKLQSPDVGKSHSSPYSRLAKSTLLLIPLFGVHYIMFAFFPNNFTAEVKMVFELVMGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGFLGSDPKYQHPSGGSNGATCSTQVSILTRVSPGARRSSSFQAEVSLV
Organism_Source Felis catus
Functional_Classification G protein-coupled receptor
Cellular_Localization plasma membrane
Gene_Names VIPR1
UniProt_ID M3WAP5
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name 4-Cl-D-Phe6
Peptide_Sequence HSDAVXTDNYTRLRKQLAVKKYLNSILN
Peptide_Length 28
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)O
Chemical_Modification X6=4-chloro-D-phenylalanine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3218.66
Aliphatic_Index 97.50000
Aromaticity 0.07143
Average_Rotatable_Bonds 3.92857
Charge_at_pH_7 3.08719
Isoelectric_Point 10.32468
Number_of_Hydrogen_Bond_Acceptors 47
Number_of_Hydrogen_Bond_Donors 51
Topological_Polar_Surface_Area 1447.90000
X_logP_energy -15.93516
Interaction Information
Affinity IC50=1.5 uM
Affinity_Assay radioligand competition binding assay
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Receptors for atrial natriuretic peptide (ANP)and cyclic GMP responses in HeLa cells.
Release_Year 1990
PMID 2158313
DOI 10.1016/0006-291x(90)91686-m