PPIRE01006

Target Protein Information
Protein_Name Gastrin-releasing peptide receptor
Protein_Sequence MDPNNCSHLNLEVDPFLSCNNTFNQTLNPPKMDNWFHPGIIYVIPAVYGLIIVIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASKYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAALIWIVSMLLAIPEAVFSDLHPFHVKDTNQTFISCAPYPHSNELHPKIHSMASFLVFYIIPLSIISVYYYFIARNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFITSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPSLLNRSHSTGRSTTCMTSFKSTNPSATFSLINGNICHEGYV
Organism_Source Rattus norvegicus
Functional_Classification G protein-coupled receptor
Cellular_Localization plasma membrane
Gene_Names Grpr
UniProt_ID P52500
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name 125I-Tyr4-Bombesin
Peptide_Sequence XQRYGNQWAVGHLM
Peptide_Length 14
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)CN)C(C)C)C(=O)O
Chemical_Modification X1=pyroglutamate; Y4=125I
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Pyroglutamate
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1616.82
Aliphatic_Index 55.71429
Aromaticity 0.14286
Average_Rotatable_Bonds 3.64286
Charge_at_pH_7 1.08804
Isoelectric_Point 9.35118
Number_of_Hydrogen_Bond_Acceptors 22
Number_of_Hydrogen_Bond_Donors 24
Topological_Polar_Surface_Area 697.49000
X_logP_energy -6.62223
Interaction Information
Affinity KD=5 nM
Affinity_Assay in vitro autoradiography
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Autoradiographic distribution of bombesin/gastrin-releasing peptide receptors in fetal cortex transplants.
Release_Year 1996
PMID 8912910
DOI 10.1006/exnr.1996.0190