PPIRE01010

Target Protein Information
Protein_Name Growth hormone secretagogue receptor type 1
Protein_Sequence MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization plasma membrane
Gene_Names GHSR
UniProt_ID Q92847
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Dpr3-octanoyl ghrelin(1-20)
Peptide_Sequence GSXFLSPEHQRVQQRKESKK
Peptide_Length 20
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)C(C)C
Chemical_Modification X3=N-octanoyl diaminopropionic acid
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2326.60
Aliphatic_Index 34.00000
Aromaticity 0.05000
Average_Rotatable_Bonds 4.15000
Charge_at_pH_7 3.09155
Isoelectric_Point 11.05848
Number_of_Hydrogen_Bond_Acceptors 35
Number_of_Hydrogen_Bond_Donors 38
Topological_Polar_Surface_Area 1102.53000
X_logP_energy -14.29436
Interaction Information
Affinity IC50=25 nM
Affinity_Assay competitive radioligand binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Stapled ghrelin peptides as fluorescent imaging probes
Release_Year 2018
PMID None
DOI 10.1002/pep2.24055