PPIRE01014
Target Protein Information
| Protein_Name | Growth hormone secretagogue receptor type 1 |
|---|---|
| Protein_Sequence | MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT |
| Organism_Source | Homo sapiens |
| Functional_Classification | G protein-coupled receptor |
| Cellular_Localization | plasma membrane |
| Gene_Names | GHSR |
| UniProt_ID | Q92847 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Cy5-labeled cyclo-12,16 Dpr3-octanoyl ghrelin(1-20) |
|---|---|
| Peptide_Sequence | GSXFLSPEHQREQQRKESKK |
| Peptide_Length | 20 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O |
| Chemical_Modification | X3=N-octanoyl diaminopropionic acid; K19=Sulfo-Cy5 |
| Cyclization_Method | Side chain-side chain cyclization; E12<->K16; amide bond |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 2356.58 |
|---|---|
| Aliphatic_Index | 19.50000 |
| Aromaticity | 0.05000 |
| Average_Rotatable_Bonds | 4.25000 |
| Charge_at_pH_7 | 2.09333 |
| Isoelectric_Point | 10.49449 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 36 |
| Number_of_Hydrogen_Bond_Donors | 39 |
| Topological_Polar_Surface_Area | 1139.83000 |
| X_logP_energy | -15.08556 |
Interaction Information
| Affinity | IC50=1 nM |
|---|---|
| Affinity_Assay | competitive radioligand binding assay |
| PDB_ID | None |
| Type | Agonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Stapled ghrelin peptides as fluorescent imaging probes |
| Release_Year | 2018 |
| PMID | None |
| DOI | 10.1002/pep2.24055 |