PPIRE01187

Target Protein Information
Protein_Name Tudor and KH domain-containing protein homolog
Protein_Sequence MLRNTPFGATPTYKLLLGFGLCSLGGAMLYAYFKTRNDEEEADSGGQRPASGIRGQTEEQKPQKEVCLKIVVDNEHVPLIMGRGGSNIKLIEEKTLAKIRLRDKDSGHKFCDISGVPDAVKAARALLIKEIERAPVVKVELQVPQRLASKINGRGGELLQEIRSSSLAKLNIDLNGRNGKAKITIIGNQKQVNIARKMLDDQIEEDEELVRSMEEVEQRREPRRSPTNSIASSMYSSQTSLSSHTQPRDKLMASKGEGKPMEVYVSAVASPTKFWVQLIGPQSKKLDSMVQEMTSYYSSAENRAKHVLTAPYVGQIVAAVFKFDEKWYRAEIVDIMPNQYNPKEQVIDLYFVDYGDSEYISPADICELRTDFLTLRFQAVECFLANVKSTIQTEPITWPKSSIAKFEELTEVAHWRKLIARVVTYKERPRATTAVSAAAKEGTPLPGVELFDPADNSELNIADLMITQGFALPLDDSYPVRSRSSTPSSNSDSTIEELCVSNPVTPLTPHSPMSMSIDVDSITQAENEHLAQQLQHLQHKLNGNDIKNINPAKLTATDLENGNNNNASTTNGASAH
Organism_Source Drosophila melanogaster
Functional_Classification Tudor domain-containing proteins
Cellular_Localization Mitochondrion
Gene_Names papi
UniProt_ID Q9VQ91
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Piwi(4-14)_unme_D287A
Peptide_Sequence XQXRGRRRPLX
Peptide_Length 11
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)CN)C(=O)NCC(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1209.38
Aliphatic_Index 35.45455
Aromaticity 0.00000
Average_Rotatable_Bonds 3.72727
Charge_at_pH_7 3.99797
Isoelectric_Point 12.97715
Number_of_Hydrogen_Bond_Acceptors 17
Number_of_Hydrogen_Bond_Donors 24
Topological_Polar_Surface_Area 636.22000
X_logP_energy -9.35722
Interaction Information
Affinity KD=0.62 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 5YGF
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural insights into the sequence-specific recognition of Piwi by Drosophila Papi.
Release_Year 2018
PMID 29531043
DOI 10.1073/pnas.1717116115