PPIRE01190

Target Protein Information
Protein_Name F-box only protein 31
Protein_Sequence MAVCARLCGVGPSRGCRRRQQRRGPAETAAADSEPDTDPEEERIEASAGVGGGLCAGPSPPPPRCSLLELPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIWRRRCREEYGVCENLRKLEITGVSCRDVYAKLLHRYRHILGLWQPDIGPYGGLLNVVVDGLFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKAATVECMYGHKGPHHGHIQIVKKDEFSTKCNQTDHHRMSGGRQEEFRTWLREEWGRTLEDIFHEHMQELILMKFIYTSQYDNCLTYRRIYLPPSRPDDLIKPGLFKGTYGSHGLEIVMLSFHGRRARGTKITGDPNIPAGQQTVEIDLRHRIQLPDLENQRNFNELSRIVLEVRERVRQEQQEGGHEAGEGRGRQGPRESQPSPAQPRAEAPSKGPDGTPGEDGGEPGDAVAAAEQPAQCGQGQPFVLPVGVSSRNEDYPRTCRMCFYGTGLIAGHGFTSPERTPGVFILFDEDRFGFVWLELKSFSLYSRVQATFRNADAPSPQAFDEMLKNIQSLTS
Organism_Source Homo sapiens
Functional_Classification ubiquitin-protein ligases
Cellular_Localization Nucleus
Gene_Names FBXO31
UniProt_ID Q5XUX0
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Cyclin D1 C-terminal peptide(residues 279-295phosphorylated Thr286)
Peptide_Sequence EQLGTKDpTYFTSPSDVDI
Peptide_Length 19
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCC(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)O
Chemical_Modification T8=phospho
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2113.26
Aliphatic_Index 56.31579
Aromaticity 0.10526
Average_Rotatable_Bonds 3.42105
Charge_at_pH_7 -3.00005
Isoelectric_Point 3.69901
Number_of_Hydrogen_Bond_Acceptors 32
Number_of_Hydrogen_Bond_Donors 30
Topological_Polar_Surface_Area 909.23000
X_logP_energy -10.48190
Interaction Information
Affinity KD=3.5 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 5VZT
Type substrate
Structure
Reference Information
Document_Type Research Articles
Title Structural basis of the phosphorylation-independent recognition of cyclin D1 by the SCFFBXO31 ubiquitin ligase.
Release_Year 2017
PMID 29279382
DOI 10.1073/pnas.1708677115