PPIRE01193
Target Protein Information
| Protein_Name | Actin-related protein 2/3 complex subunit 4 |
|---|---|
| Protein_Sequence | MSNTLRPYLNAVRSTLTASLALEEFSSEIVERQSQPEVEVGRSPEILLKPLVVSRNEQEQCLIESSVNSVRFSIRIKQVDEIERILVRKFMQFLMGRAESFFILRRKPVQGYDISFLITNYHTEEMLKHKLVDFIIEFMEEVDAEISEMKLFLNGRARLVAETYLSCF |
| Organism_Source | Schizosaccharomyces pombe (strain 972 / ATCC 24843) |
| Functional_Classification | actin nucleation complex |
| Cellular_Localization | Cytoplasm |
| Gene_Names | arc4 |
| UniProt_ID | Q92352 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Wsp1p-CA |
|---|---|
| Peptide_Sequence | XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX |
| Peptide_Length | 33 |
| Peptide_SMILES | NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1900.73 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 1.96970 |
| Charge_at_pH_7 | -0.00202 |
| Isoelectric_Point | 6.10000 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 34 |
| Number_of_Hydrogen_Bond_Donors | 34 |
| Topological_Polar_Surface_Area | 994.52000 |
| X_logP_energy | -29.25190 |
Interaction Information
| Affinity | KD=0.13 uM |
|---|---|
| Affinity_Assay | Isothermal titration calorimetry |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Structural and biochemical characterization of two binding sites for nucleation-promoting factor WASp-VCA on Arp2/3 complex. |
| Release_Year | 2011 |
| PMID | 21676862 |
| DOI | 10.1073/pnas.1100125108 |