PPIRE01254

Target Protein Information
Protein_Name Chromobox protein homolog 1
Protein_Sequence MGKKQNKKKVEEVLEEEEEEYVVEKVLDRRVVKGKVEYLLKWKGFSDEDNTWEPEENLDCPDLIAEFLQSQKTAHETDKSEGGKRKADSDSEDKGEESKPKKKKEESEKPRGFARGLEPERIIGATDSSGELMFLMKWKNSDEADLVPAKEANVKCPQVVISFYEERLTWHSYPSEDDDKKDDKN
Organism_Source Mus musculus
Functional_Classification chromodomain
Cellular_Localization nucleus
Gene_Names Cbx1
UniProt_ID P83917
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Histone H3(1-18)K4me3K9me3 peptide
Peptide_Sequence ARTXQTARXSTGGKAPGG
Peptide_Length 18
Peptide_SMILES C[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)NCC(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification X4=N,N-diethyllysine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1629.75
Aliphatic_Index 16.66667
Aromaticity 0.00000
Average_Rotatable_Bonds 2.94444
Charge_at_pH_7 2.99768
Isoelectric_Point 12.51648
Number_of_Hydrogen_Bond_Acceptors 27
Number_of_Hydrogen_Bond_Donors 30
Topological_Polar_Surface_Area 823.06000
X_logP_energy -15.95006
Interaction Information
Affinity KD=1.94 mM
Affinity_Assay intrinsic tryptophan fluorescence
PDB_ID 1GUW
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9.
Release_Year 2002
PMID 11882902
DOI 10.1038/nature722