PPIRE01304

Target Protein Information
Protein_Name Immunoglobulin heavy constant gamma 1
Protein_Sequence ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFKVKWIFSSVVDLKQTIIPDYRNMIGQGA
Organism_Source Homo sapiens
Functional_Classification immunoglobulins
Cellular_Localization extracellular
Gene_Names IGHG1
UniProt_ID P01857
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name LH1
Peptide_Sequence FNMXQQRRFYXALH
Peptide_Length 14
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O
Chemical_Modification X4=Fmoc-glutamic acid O-(5-allyloxycarbonyl-1-5-diaminopentane); X11=Fmoc-glutamic acid O-allyl ester
Cyclization_Method Side chain-side chain cyclization; X4<->X11; other bonds
Linear/Cyclic Cyclic
N-terminal_Modification Succinyl
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1724.96
Aliphatic_Index 35.00000
Aromaticity 0.21429
Average_Rotatable_Bonds 4.00000
Charge_at_pH_7 2.08804
Isoelectric_Point 11.14768
Number_of_Hydrogen_Bond_Acceptors 23
Number_of_Hydrogen_Bond_Donors 26
Topological_Polar_Surface_Area 743.60000
X_logP_energy -6.88496
Interaction Information
Affinity KD=1 mM
Affinity_Assay Surface plasmon resonance
PDB_ID 5U66
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title 3-2-1: Structural insights from stepwise shrinkage of a three-helix Fc-binding domain to a single helix.
Release_Year 2017
PMID 28475752
DOI 10.1093/protein/gzx029