PPIRE01349
Target Protein Information
| Protein_Name | Tissue factor |
|---|---|
| Protein_Sequence | METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPKPVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGSAGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFGKDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVECMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS |
| Organism_Source | Homo sapiens |
| Functional_Classification | receptor cofactor |
| Cellular_Localization | plasma membrane |
| Gene_Names | F3 |
| UniProt_ID | P13726 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | FVII(177-206)peptide |
|---|---|
| Peptide_Sequence | EFEGPVNWDLGKPQNGTLSEGKFKKHLDGS |
| Peptide_Length | 30 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(=O)O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 3315.65 |
|---|---|
| Aliphatic_Index | 48.66667 |
| Aromaticity | 0.10000 |
| Average_Rotatable_Bonds | 3.70000 |
| Charge_at_pH_7 | -0.90607 |
| Isoelectric_Point | 5.65204 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 47 |
| Number_of_Hydrogen_Bond_Donors | 46 |
| Topological_Polar_Surface_Area | 1414.65000 |
| X_logP_energy | -14.96210 |
Interaction Information
| Affinity | Ki=7 uM |
|---|---|
| Affinity_Assay | Surface plasmon resonance |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | A novel gene mutation in the 60s loop of human coagulation factor VII - inhibition of interdomain crosstalk. |
| Release_Year | 2004 |
| PMID | 14691565 |
| DOI | 10.1160/TH03-05-0258 |