PPIRE01353
Target Protein Information
| Protein_Name | None |
|---|---|
| Protein_Sequence | MKTFVTEALFLLLQVLLAMTSHPDGTHFFGFFQTLFTLPWMPKPQFISVGFVDDIQFERFNSRRDVQRTEHCAPWKDQKKPEYWKDNTDLVLSYFQDLTEILQRMLKIYNYSLTGYHTIQRRYGCYILPRGYFRNGFFEVVFNDHDSIRLNEDLSTWTPVGKFAEILREEWDSSGFTQNVKNFLEVECVDLFLTELEYGKEILLRTDIPKIHVIRKVRPDKKITLRCWALKFYPAEITLTWERDKSNQTLDMEVTETMPTGDGTFQKWAAVVVLSGEEHRYKCHVNHEGLPEPITLRWVPPEPTISFMHIVIVVVLGALLMGAMMTLLIWKRRTR |
| Organism_Source | Mus musculus |
| Functional_Classification | Bcl-2 family |
| Cellular_Localization | Cytoplasm |
| Gene_Names | H2-M11 |
| UniProt_ID | F6U8V3 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | L112A Beclin 1 BH3 peptide |
|---|---|
| Peptide_Sequence | ANLLAQLADLGV |
| Peptide_Length | 12 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)N)C(=O)NCC(=O)N[C@H](C(=O)O)C(C)C |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1197.40 |
|---|---|
| Aliphatic_Index | 179.16667 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.25000 |
| Charge_at_pH_7 | -1.00157 |
| Isoelectric_Point | 3.74999 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 16 |
| Number_of_Hydrogen_Bond_Donors | 16 |
| Topological_Polar_Surface_Area | 506.90000 |
| X_logP_energy | -4.12180 |
Interaction Information
| Affinity | KD=177.62 uM |
|---|---|
| Affinity_Assay | Isothermal titration calorimetry |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Targeting Gamma-herpesvirus 68 Bcl-2-mediated down-regulation of autophagy. |
| Release_Year | 2014 |
| PMID | 24443581 |
| DOI | 10.1074/jbc.M113.515361 |