PPIRE01382

Target Protein Information
Protein_Name Gem-associated protein 2
Protein_Sequence MRRAELAGLKTMAWVPAESAVEELMPRLLPVEPCDLTEGFDPSVPPRTPQEYLRRVQIEAAQCPDVVVAQIDPKKLKRKQSVNISLSGCQPAPEGYSPTLQWQQQQVAQFSTVRQNVNKHRSHWKSQQLDSNVTMPKSEDEEGWKKFCLGEKLCADGAVGPATNESPGIDYVQIGFPPLLSIVSRMNQATVTSVLEYLSNWFGERDFTPELGRWLYALLACLEKPLLPEAHSLIRQLARRCSEVRLLVDSKDDERVPALNLLICLVSRYFDQRDLADEPS
Organism_Source Homo sapiens
Functional_Classification scaffolding proteins
Cellular_Localization Cytoplasm
Gene_Names GEMIN2
UniProt_ID O14893
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name SMN26-51_D35A
Peptide_Sequence MADIAGGELPSLEDLEKDLKEQEELG
Peptide_Length 26
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2830.11
Aliphatic_Index 97.69231
Aromaticity 0.00000
Average_Rotatable_Bonds 3.88462
Charge_at_pH_7 -6.99062
Isoelectric_Point 3.61221
Number_of_Hydrogen_Bond_Acceptors 41
Number_of_Hydrogen_Bond_Donors 39
Topological_Polar_Surface_Area 1233.09000
X_logP_energy -10.88310
Interaction Information
Affinity KD=1.3 nM
Affinity_Assay Fluorescence Polarization
PDB_ID 2LEH
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Solution structure of the core SMN-Gemin2 complex.
Release_Year 2012
PMID 22607171
DOI 10.1042/BJ20120241