PPIRE01410
Target Protein Information
| Protein_Name | T cell receptor alpha chain constant |
|---|---|
| Protein_Sequence | IQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPSPESSCDVKLVEKSFETDTNLNFQNLSVIGFRILLLKVAGFNLLMTLRLWSS |
| Organism_Source | Homo sapiens |
| Functional_Classification | immunoglobulin superfamily receptors |
| Cellular_Localization | plasma membrane |
| Gene_Names | TRAC |
| UniProt_ID | P01848 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Tax-Y5F3-4FF |
|---|---|
| Peptide_Sequence | LLFGXPVYV |
| Peptide_Length | 9 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)O)C(C)C)C(C)C |
| Chemical_Modification | X5=3-4-di?uoro-phenylalanine |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 964.17 |
|---|---|
| Aliphatic_Index | 151.11111 |
| Aromaticity | 0.22222 |
| Average_Rotatable_Bonds | 2.88889 |
| Charge_at_pH_7 | -0.00287 |
| Isoelectric_Point | 6.09320 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 11 |
| Number_of_Hydrogen_Bond_Donors | 10 |
| Topological_Polar_Surface_Area | 307.56000 |
| X_logP_energy | 0.64090 |
Interaction Information
| Affinity | KD=3 nM |
|---|---|
| Affinity_Assay | Isothermal titration calorimetry |
| PDB_ID | None |
| Type | Agonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Fluorine substitutions in an antigenic peptide selectively modulate T-cell receptor binding in a minimally perturbing manner. |
| Release_Year | 2009 |
| PMID | 19698083 |
| DOI | 10.1042/BJ20090732 |