PPIRE01429

Target Protein Information
Protein_Name Regulation of nuclear pre-mRNA domain-containing protein 1A
Protein_Sequence MSAFSEAALEKKLSELSNSQQSVQTLSLWLIHHRKHSRPIVTVWERELRKAKPNRKLTFLYLANDVIQNSKRKGPEFTKDFAPVIVEAFKHVSSETDESCKKHLGRVLSIWEERSVYENDVLEQLKQALYGDKKPRKRTYEQIKVDENENCSSLGSPSEPPQTLDLVRALQDLENAASGDAAVHQRIASLPVEVQEVSLLDKITDKESGERLSKMVEDACMLLADYNGRLAAEIDDRKQLTRMLADFLRCQKEALAEKEHKLEEYKRKLARVSLVRKELRSRIQSLPDLSRLPNVTGSHMHLPFAGDIYSED
Organism_Source Homo sapiens
Functional_Classification CTD-interacting scaffold protein
Cellular_Localization nucleus
Gene_Names RPRD1A
UniProt_ID Q96P16
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name S2P CTD
Peptide_Sequence SPSYSPTSPSYSPTSPSYS
Peptide_Length 19
Peptide_SMILES C[C@@H](O)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CO)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification S5=phospho; S12=phospho
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1979.04
Aliphatic_Index 0.00000
Aromaticity 0.15789
Average_Rotatable_Bonds 2.57895
Charge_at_pH_7 -0.00457
Isoelectric_Point 6.08020
Number_of_Hydrogen_Bond_Acceptors 34
Number_of_Hydrogen_Bond_Donors 29
Topological_Polar_Surface_Area 826.39000
X_logP_energy -14.80710
Interaction Information
Affinity KD=8.4 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation.
Release_Year 2014
PMID 24997600
DOI 10.1038/nsmb.2853