PPIRE01475

Target Protein Information
Protein_Name Actin nucleation-promoting factor WASL
Protein_Sequence MSSVQQQPPPPRRVTNVGSLLLTPQENESLFTFLGKKCVTMSSAVVQLYAADRNCMWSKKCSGVACLVKDNPQRSYFLRIFDIKDGKLLWEQELYNNFVYNSPRGYFHTFAGDTCQVALNFANEEEAKKFRKAVTDLLGRRQRKSEKRRDPPNGPNLPMATVDIKNPEITTNRFYGPQVNNISHTKEKKKGKAKKKRLTKADIGTPSNFQHIGHVGWDPNTGFDLNNLDPELKNLFDMCGISEAQLKDRETSKVIYDFIEKTGGVEAVKNELRRQAPPPPPPSRGGPPPPPPPPHNSGPPPPPARGRGAPPPPPSRAPTAAPPPPPPSRPSVAVPPPPPNRMYPPPPPALPSSAPSGPPPPPPSVLGVGPVAPPPPPPPPPPPGPPPPPGLPSDGDHQVPTTAGNKAALLDQIREGAQLKKVEQNSRPVSCSGRDALLDQIRQGIQLKSVADGQESTPPTPAPTSGIVGALMEVMQKRSKAIHSSDEDEDEDDEEDFEDDDEWED
Organism_Source Homo sapiens
Functional_Classification nucleation promoting factors
Cellular_Localization Cytoplasm
Gene_Names WASL
UniProt_ID O00401
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name EspFU H motif
Peptide_Sequence DVAQRLMQHLAEH
Peptide_Length 13
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1547.75
Aliphatic_Index 97.69231
Aromaticity 0.00000
Average_Rotatable_Bonds 4.00000
Charge_at_pH_7 -0.81798
Isoelectric_Point 6.49987
Number_of_Hydrogen_Bond_Acceptors 22
Number_of_Hydrogen_Bond_Donors 23
Topological_Polar_Surface_Area 692.56000
X_logP_energy -6.17763
Interaction Information
Affinity KD=0.035 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 2LNH
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Enterohaemorrhagic Escherichia coli exploits a tryptophan switch to hijack host f-actin assembly.
Release_Year 2012
PMID 22921828
DOI 10.1016/j.str.2012.07.015