PPIRE01478

Target Protein Information
Protein_Name BAR/IMD domain-containing adapter protein 2-like 1
Protein_Sequence MSRGPEEVNRLTESTYRNVMEQFNPGLRNLINLGKNYEKAVNAMILAGKAYYDGVAKIGEIATGSPVSTELGHVLIEISSTHKKLNESLDENFKKFHKEIIHELEKKIELDVKYMNATLKRYQTEHKNKLESLEKSQAELKKIRRKSQGSRNALKYEHKEIEYVETVTSRQSEIQKFIADGCKEALLEEKRRFCFLVDKHCGFANHIHYYHLQSAELLNSKLPRWQETCVDAIKVPEKIMNMIEEIKTPASTPVSGTPQASPMIERSNVVRKDYDTLSKCSPKMPPAPSGRAYTSPLIDMFNNPATAAPNSQRVNNSTGTSEDPSLQRSVSVATGLNMMKKQKVKTIFPHTAGSNKTLLSFAQGDVITLLIPEEKDGWLYGEHDVSKARGWFPSSYTKLLEENETEAVTVPTPSPTPVRSISTVNLSENSSVVIPPPDYLECLSMGAAADRRADSARTTSTFKAPASKPETAAPNDANGTAKPPFLSGENPFATVKLRPTVTNDRSAPIIR
Organism_Source Homo sapiens
Functional_Classification SH3 adaptor proteins
Cellular_Localization plasma membrane
Gene_Names BAIAP2L1
UniProt_ID Q9UHR4
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name EspFU P motif W33A
Peptide_Sequence IPPAPNAPAPTPP
Peptide_Length 13
Peptide_SMILES CC[C@H](C)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1239.44
Aliphatic_Index 53.07692
Aromaticity 0.00000
Average_Rotatable_Bonds 1.76923
Charge_at_pH_7 -0.00202
Isoelectric_Point 6.10000
Number_of_Hydrogen_Bond_Acceptors 16
Number_of_Hydrogen_Bond_Donors 9
Topological_Polar_Surface_Area 414.31000
X_logP_energy -3.87870
Interaction Information
Affinity KD=22.3 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 2LNH
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Enterohaemorrhagic Escherichia coli exploits a tryptophan switch to hijack host f-actin assembly.
Release_Year 2012
PMID 22921828
DOI 10.1016/j.str.2012.07.015