PPIRE01482
Target Protein Information
| Protein_Name | Actin, alpha skeletal muscle |
|---|---|
| Protein_Sequence | MCDEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF |
| Organism_Source | Oryctolagus cuniculus |
| Functional_Classification | Cytoskeletal proteins |
| Cellular_Localization | Cytoplasm |
| Gene_Names | ACTA1 |
| UniProt_ID | P68135 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | IRSp53 WH2 peptide(isoform 2) |
|---|---|
| Peptide_Sequence | GPDGKVPQEEWSLLGVEGLVVEKDDLLEEL |
| Peptide_Length | 30 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)CN)C(C)C)C(C)C)C(C)C)C(C)C)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 3293.67 |
|---|---|
| Aliphatic_Index | 116.66667 |
| Aromaticity | 0.03333 |
| Average_Rotatable_Bonds | 3.70000 |
| Charge_at_pH_7 | -6.99062 |
| Isoelectric_Point | 3.61221 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 44 |
| Number_of_Hydrogen_Bond_Donors | 43 |
| Topological_Polar_Surface_Area | 1356.49000 |
| X_logP_energy | -9.25120 |
Interaction Information
| Affinity | KD=0.28 mM |
|---|---|
| Affinity_Assay | Isothermal titration calorimetry |
| PDB_ID | 2D1K |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Structural basis for the actin-binding function of missing-in-metastasis. |
| Release_Year | 2007 |
| PMID | 17292833 |
| DOI | 10.1016/j.str.2006.12.005 |