PPIRE01497

Target Protein Information
Protein_Name None
Protein_Sequence MSVQRALHYYLCSQLLLHLYAVEGSYHERRLYEDLMRDYNNLERPVANHSQPVTVYLKVSLQQIIDVDEKNQIVYVNAWLDYAWNDYKLRWDKEEYGNITDVRFPAGKIWKPDVLLYNSVDANFDSTYPTNMVVYNTGDISWIPPGIFKISCKIDIKWFPFDEQRCFFKFGSWTYDGFKLDLQPGKGGFDISEYMPSGEWALPMTTVSRTEKFYDCCPEPYPDLTFYLHMRRRTLYYGFNLIMPCILTTMMTLLGFTLPPDAGEKITLQITVLLSICFFLSIVSEISPPTSEAVPLLGIFFSCCMIVVTASTVFTVYVLNLHYRTPETHEMGITTRTLLLYWFPYILRMERPGVYLTWQTLPPLFPCSKPKKHSESLIRNVKDVETGSSRSNSLDVERRVHQYMSGLTNGTGAPMCTVLNGGPATVAGAPMDIGQQATLLVLQRIYQELKTITRRMIEADREGAQSNNWKFAAMVVDRLCLYVFTVFIVASSCGILLSAPYTIA
Organism_Source Ascaris suum
Functional_Classification ligand-gated ion channels
Cellular_Localization plasma membrane
Gene_Names acr-16
UniProt_ID A0A0K0QSL7
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name NLP-2A
Peptide_Sequence PRFGQRGYAMSa
Peptide_Length 12
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1340.52
Aliphatic_Index 16.66667
Aromaticity 0.16667
Average_Rotatable_Bonds 3.50000
Charge_at_pH_7 1.99713
Isoelectric_Point 11.14762
Number_of_Hydrogen_Bond_Acceptors 19
Number_of_Hydrogen_Bond_Donors 22
Topological_Polar_Surface_Area 576.78000
X_logP_energy -6.81316
Interaction Information
Affinity IC50=78 uM
Affinity_Assay organ bath contraction assay
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title The actions of Caenorhabditis elegans neuropeptide-like peptides (NLPs)on body wall muscle of Ascaris suum and pharyngeal muscle of C. elegans.
Release_Year 2008
PMID 18652392
DOI 10.1556/ABiol.59.2008.Suppl.28