PPIRE01504

Target Protein Information
Protein_Name Mas-related G-protein coupled receptor member X2
Protein_Sequence MDPTTPAWGTESTTVNGNDQALLLLCGKETLIPVFLILFIALVGLVGNGFVLWLLGFRMRRNAFSVYVLSLAGADFLFLCFQIINCLVYLSNFFCSISINFPSFFTTVMTCAYLAGLSMLSTVSTERCLSVLWPIWYRCRRPRHLSAVVCVLLWALSLLLSILEGKFCGFLFSDGDSGWCQTFDFITAAWLIFLFMVLCGSSLALLVRILCGSRGLPLTRLYLTILLTVLVFLLCGLPFGIQWFLILWIWKDSDVLFCHIHPVSVVLSSLNSSANPIIYFFVGSFRKQWRLQQPILKLALQRALQDIAEVDHSEGCFRQGTPEMSRSSLV
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization plasma membrane
Gene_Names MRGPRX2
UniProt_ID Q96LB1
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name PAMP
Peptide_Sequence ARLDVASEFRKKWNKWALSR
Peptide_Length 20
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2461.86
Aliphatic_Index 68.50000
Aromaticity 0.15000
Average_Rotatable_Bonds 4.15000
Charge_at_pH_7 3.99931
Isoelectric_Point 11.65059
Number_of_Hydrogen_Bond_Acceptors 32
Number_of_Hydrogen_Bond_Donors 40
Topological_Polar_Surface_Area 1069.71000
X_logP_energy -8.51559
Interaction Information
Affinity KD=110 nM
Affinity_Assay radioligand binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Proadrenomedullin NH(2)-terminal 20 peptide (PAMP)and adrenomedullin bind to teratocarcinoma cells.
Release_Year 2000
PMID 10704725
DOI 10.1016/S0196-9781(99)00178-3