PPIRE01535

Target Protein Information
Protein_Name H-2 class II histocompatibility antigen, I-A beta chain
Protein_Sequence MVWLPRVPCVAAVILLLTVLSPPVALVRDSRPWFLEYCKSECHFYNGTQRVRFLKRYFYNLEENLRFDSDVGEFRAVTELGRPDAENWNSQPEILDEKRAAVDTYCRHNYEIFDNFLVPRRVEPTVTVYPTKTQPLEHHNLLVCSVSDFYPGNIEVRWFRNGKEEKTGIVSTGLVRNGDWTFQTLVMLETVPQSGEVYTCQVEHPSLTDPVTVEWKAQSTSAQNKMLSGVGGFVLGLLFLRAGLFIYFRNQKGQSGLQPTGLLS
Organism_Source Mus musculus
Functional_Classification Immune-related protein
Cellular_Localization Plasma membrane
Gene_Names H2-Eb1
UniProt_ID P18468
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name MCC-p5E
Peptide_Sequence MANERADLIAYLEQATK
Peptide_Length 17
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1937.20
Aliphatic_Index 92.35294
Aromaticity 0.05882
Average_Rotatable_Bonds 3.88235
Charge_at_pH_7 -0.99917
Isoelectric_Point 4.42641
Number_of_Hydrogen_Bond_Acceptors 28
Number_of_Hydrogen_Bond_Donors 29
Topological_Polar_Surface_Area 855.38000
X_logP_energy -7.80733
Interaction Information
Affinity KD=500 uM
Affinity_Assay Surface plasmon resonance
PDB_ID 3QIW
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Structural basis of specificity and cross-reactivity in T cell receptors specific for cytochrome c-I-E(k).
Release_Year 2011
PMID 21490152
DOI 10.4049/jimmunol.1100197