PPIRE01543
Target Protein Information
| Protein_Name | Packaging protein UL32 |
|---|---|
| Protein_Sequence | MATSPPGVLASVAVCEESPGSSWKAGAFERAYVAFDPSLLALNEALCAELLTASHVIGVPPVGTLDEDVAADVVTAPSRARGGAGDGGGSGGRGGPRNPPPDPCGEGLLDTGPFSAAAIDTFALDRPCLVCRTIELYKQTYRLSPQWVADYAFLCAKCLGAPHCAASIFVAAFEFVYVMDRHFLRTKKATLVGSFARFALTINDIHRHFFLHCCFRTDGGVPGRHAQKQPKPSPSPGAAKVQYSNYSFLAQSATRALIGTLASGGEEGAGSAAGSGTQPSLTTALMNWKDCARLLDCTEGRRGGGDSCCTRAAARNGEFETVAGDREPEESPDTWAYADLVLLLLAGTPAVWESGPQLRAAAEARRATVRQSWEAHRGARTRDVAPRFAQFTEPDAQPDLDLGPLMATVLKHGRGRGRTGGECLLCNLLLVRAYWLALRRLRASVVRYSENNTSLFDCIVPVVDQLEADPETQPGDGGRFVSLLRAAGPEAIFKHMFCDPMCAITEMEVDPWVLFGHPPATHPDELLLHKAKLACGNEFEGRVCIALRALIYTFKTYQVFVPKPTALATFVREAGALLRRHSISLLSLEHTLCTYV |
| Organism_Source | Human herpesvirus 1 (strain 17) |
| Functional_Classification | Viral envelope proteins |
| Cellular_Localization | Nucleus |
| Gene_Names | UL32 |
| UniProt_ID | P10216 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | pep-CR2 |
|---|---|
| Peptide_Sequence | NKLVYTGRL |
| Peptide_Length | 9 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)O)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Other |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1063.27 |
|---|---|
| Aliphatic_Index | 118.88889 |
| Aromaticity | 0.11111 |
| Average_Rotatable_Bonds | 3.88889 |
| Charge_at_pH_7 | 1.99684 |
| Isoelectric_Point | 10.45492 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 15 |
| Number_of_Hydrogen_Bond_Donors | 17 |
| Topological_Polar_Surface_Area | 467.59000 |
| X_logP_energy | -3.74693 |
Interaction Information
| Affinity | IC50=1.33 uM |
|---|---|
| Affinity_Assay | NMR chemical shift perturbation |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Tegument Protein pp150 Sequence-Specific Peptide Blocks Cytomegalovirus Infection. |
| Release_Year | 2021 |
| PMID | 34835083 |
| DOI | 10.3390/v13112277 |