PPIRE01656

Target Protein Information
Protein_Name 14-3-3 protein epsilon
Protein_Sequence MDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDGEEQNKEALQDVEDENQ
Organism_Source Homo sapiens
Functional_Classification E3 ubiquitin ligase adaptors
Cellular_Localization Cytoplasm
Gene_Names YWHAE
UniProt_ID P62258
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name pS
Peptide_Sequence TQRQNXAPARMLSS
Peptide_Length 14
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification X6=phosphoserine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1516.70
Aliphatic_Index 42.14286
Aromaticity 0.00000
Average_Rotatable_Bonds 3.57143
Charge_at_pH_7 1.99798
Isoelectric_Point 12.50011
Number_of_Hydrogen_Bond_Acceptors 24
Number_of_Hydrogen_Bond_Donors 26
Topological_Polar_Surface_Area 746.59000
X_logP_energy -12.02436
Interaction Information
Affinity KD=0.22 uM
Affinity_Assay Surface plasmon resonance
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title The Development of CDC25A-Derived Phosphoseryl Peptides That Bind 14-3-3钄 with High Affinities.
Release_Year 2024
PMID 38732131
DOI 10.3390/ijms25094918